The Number Your Doctor Does Not Tell You
Atorvastatin is the most dispensed drug in England at 65 million items in 2023/24.
Between 2004 and 2018, the NHS spent £6.3 billion on statins in primary care.
Research suggests £2.8 billion, approximately forty percent, could have been saved through optimal prescribing.
For secondary prevention in people with existing heart disease, the benefit is clear: NNT of 15 to 33 to prevent one death over 5 years.
For primary prevention in otherwise healthy people, the Cochrane meta-analysis found an NNT of 138 to prevent one death over 5 years.
For the lowest risk patients now eligible under NICE's 2014 expanded threshold, the NNT rises to 400.
The number needed to harm for new onset diabetes is 99 over 5 years.
For muscle pain, approximately twenty one.
NHS BSA prescribing data 2023/24; Cochrane statin meta-analysis; NICE CG181